High-Potency B12 Methylcobalamin 3000 mcg with Folate, Allergy Research Group
High-potency bioavailable methylcobalamin to support nerve health, cognitive function, and methylation balance.*
Derek says, "This is the B-12 I used to recover after my diagnosis (University of Florida's Neuromedicine Hospital) with a severe B12 deficiency (a potential downside of long-term use of the diabetes drug, metformin) that led to serious nerve damage compromising my balance and leading to 45 hard bowling pin-like falls in three weeks alone.
"By the grace of God, I recovered with neuro-physical therapy, 6-months, twice weekly, and by restoring my B12 levels to normal.
"I chose Allergy Research Group's Methylcobalamin B12—3,000 mcg per lozenge—despite having a prescription for injectable B12 or weaker products that don't cost as much but you have to take three to six servings to match the potency of ARG's B12.
"I still take them daily—and will—for the rest of my life. Being 74 as I write this, paying attention to my B12 levels makes sense. As studies strongly suggest, B12 is crucially important for nerve repair, cognitive function, and red blood cell production. It is heavily used in clinical settings to treat peripheral neuropathy, chronic fatigue, and cognitive decline. To ice the cake, B12 is snow the focus of intensive study in the treatment of PAIN (NIH report). *
B12 Methylcobalamin 3000 mcg with Folate is a high-potency formula providing methylated vitamin B12 with folate to support nerve health, red blood cell production, and homocysteine metabolism.* Methylcobalamin is the active form used in the brain and central nervous system and plays a role in neurotransmitter synthesis, myelin formation, and energy production.* Oral doses of 1,000 mcg and above are shown to be effective for maintaining healthy B12 levels.* Ideal for individuals with increased needs due to aging, medications, or dietary patterns, B12 Methylcobalamin 3,000 mcg offers safe, research-backed support for healthy cognition, mood, and methylation.*
What It Does
B12 Methylcobalamin 3,000 mcg with Folate supports neurological health, red blood cell formation, and cellular energy by delivering a bioavailable, high-dose form of vitamin B12.* It promotes methylation, emotional well-being, and homocysteine regulation in lozenge form supported by 400 mcg of methylfolate and vitamin C.*
How It Works
• Methylcobalamin (Vitamin B12): The active, methylated form of B12 used in the central nervous system and involved in myelin sheath formation, neurotransmitter production, and cellular metabolism.*[1,4,8]
• Methylfolate: Works alongside B12 to support methylation, red blood cell production, and homocysteine metabolism.*[1]
• Homocysteine Balance: B12 facilitates the conversion of homocysteine to methionine, contributing to cardiovascular and cognitive health.*[6]
• Nerve Protection: Methylcobalamin supports myelin synthesis, essential for normal nerve signal transmission and neurological function.*[4,9]
• Mood and Cognition: B12 plays a role in the synthesis of neurotransmitters related to emotional regulation and mental clarity; insufficient levels may impact mood and cognition.*[3,8,10]
• Oral Absorption: Systematic reviews show oral doses of 1,000 mcg or more are effective compared to alternative administration.*[11]
• Low Toxicity: No tolerable upper intake level (UL) is established for B12 due to its safety profile and water-solubility, allowing the body to excrete excess amounts efficiently.*[12]
Who It’s For
This product is ideal for individuals with increased B12 needs due to dietary restrictions, aging, vitamin B-12 depleting medication use, or those seeking to support mood, cognition, and neurological function with a clinically supported dose.*
Special Features
Delivers 3,000 mcg of methylcobalamin per lozenge for reliable, high-potency support in a bioavailable format. Combined with folate to engage methylation and optimize homocysteine metabolism.*
B12 Methylcobalamin 3,000 mcg with Folate offers research-backed, high-dose neurological and metabolic support in one convenient daily lozenge.*
References
1. Baltrusch S. Biomed Res Int. 2021;2021:9968228. doi:10.1155/2021/9968228
2. Pawlak R, et al. Eur J Clin Nutr. 2014;68(5):541–8.
3. Lachner C, et al. J Neuropsychiatry Clin Neurosci. 2012;24(1):5–15.
4. Mumtaz H, et al. Ann Med Surg (Lond). 2022;82:104762. doi:10.1016/j.amsu.2022.104762
5. Infante M, et al. World J Diabetes. 2021;12(7):916–31.
6. Ueno A, et al. Nutrients. 2022;14(7):1494. doi:10.3390/nu14071494
7. Sangle P, et al. Cureus. 2020;12(10):e11169. doi:10.7759/cureus.11169
8. Syed EU, et al. Open Neurol J. 2013;7:44–8.
9. Calderon-Ospina CA, Nava-Mesa MO. CNS Neurosci Ther. 2020;26(1):5–13.
10. Beaudry-Richard A, et al. Ann Neurol. 2025. doi:10.1002/ana.27200
11. Wang H, et al. Cochrane Database Syst Rev. 2018;3(3):CD004655
12. Institute of Medicine. Dietary Reference Intakes. National Academies Press. 1998.
* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
